Yuflyma (adalimumab-aaty) vs Nanozora (ozoralizumab)

Yuflyma (adalimumab-aaty) vs Nanozora (ozoralizumab)

Yuflyma (adalimumab-aaty) is a biosimilar to the original adalimumab formulation, a tumor necrosis factor (TNF) blocker used to treat various inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and Crohn's disease. Nanozora (ozoralizumab), on the other hand, is a nanobody that also targets TNF, but with a different structure and potentially different pharmacokinetics, and is under investigation for similar indications. When deciding between the two, patients should consider factors such as the specific condition being treated, the medicine's approval status and available clinical data, potential side effects, and the advice of their healthcare provider.

Difference between Yuflyma and Nanozora

Metric Yuflyma (adalimumab-aaty) Nanozora (ozoralizumab)
Generic name adalimumab-aaty ozoralizumab
Indications Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis Currently under investigation, potential use in rheumatoid arthritis
Mechanism of action TNF inhibitor Anti-TNF nanobody
Brand names Yuflyma Nanozora (not yet commercially available)
Administrative route Subcutaneous injection Subcutaneous injection (anticipated)
Side effects Infections, injection site reactions, headache, rash Currently under investigation, not fully characterized
Contraindications Active tuberculosis, severe infections, hypersensitivity to adalimumab or excipients Not yet fully characterized
Drug class Monoclonal antibody Nanobody
Manufacturer Celltrion Healthcare Not yet available; under development

Efficacy

Introduction to Yuflyma (adalimumab-aaty)

Yuflyma (adalimumab-aaty) is a biosimilar to the reference product adalimumab, a well-known biologic medication used to treat several inflammatory conditions, including rheumatoid arthritis (RA). As a tumor necrosis factor (TNF) inhibitor, Yuflyma works by blocking the action of TNF, a substance in the body that causes inflammation and can lead to autoimmune disorders such as RA. The efficacy of Yuflyma in the treatment of rheumatoid arthritis has been demonstrated in clinical trials where it has shown to reduce signs and symptoms, improve physical function, and inhibit the progression of structural damage in patients with moderately to severely active RA.

Efficacy of Yuflyma in Rheumatoid Arthritis

In clinical studies, Yuflyma has been shown to be effective in reducing the pain and swelling associated with rheumatoid arthritis. Patients treated with Yuflyma have reported improvements in joint stiffness and mobility. The medication has also been found to slow the progression of joint damage, which is a critical aspect of managing RA over the long term. The efficacy of Yuflyma in RA makes it a valuable treatment option for patients who may not respond to traditional disease-modifying antirheumatic drugs (DMARDs) or for whom other biologics are not suitable.

Introduction to Nanozora (ozoralizumab)

Nanozora (ozoralizumab) is a novel biologic medication that targets and neutralizes TNF, similar to other TNF inhibitors, but with a unique nanobody structure that allows for a smaller size and potentially different pharmacokinetics. Although not as widely known or used as adalimumab biosimilars, Nanozora has shown promise in the treatment of rheumatoid arthritis. The efficacy of Nanozora in RA has been evaluated in clinical trials, focusing on its ability to alleviate symptoms, improve quality of life, and manage the chronic nature of the disease.

Efficacy of Nanozora in Rheumatoid Arthritis

Studies on Nanozora have reported significant improvements in RA symptoms, with patients experiencing reduced joint pain and swelling. The medication has also been associated with improvements in physical function, allowing patients to perform daily activities with greater ease. Furthermore, Nanozora has demonstrated a potential to inhibit the progression of joint damage, which is crucial for maintaining joint function and preventing disability in RA patients. While more research may be needed to fully understand the long-term efficacy and safety profile of Nanozora, initial results are promising for its use as a treatment option in rheumatoid arthritis.

Regulatory Agency Approvals

Yuflyma
  • European Medical Agency (EMA), European Union
  • Food and Drug Administration (FDA), USA
Nanozora
  • Pharmaceuticals and Medical Devices Agency (PMDA), Japan

Access Yuflyma or Nanozora today

If Yuflyma or Nanozora are not approved or available in your country (e.g. due to supply issues), you can access them via Everyone.org.

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